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|Tested species reactivity||Human , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627 (V-E-YP-L-D)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GRB2-associated binder 1, GRB2-associated-binding protein 1, growth factor receptor bound protein 2-associated protein 1, GAB1
Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Intracellular signaling cascade MAPKKK cascade Immunity and defense T-cell mediated immunity B-cell- and antibody-mediated immunity Macrophage-mediated immunity Cytokine/chemokine mediated immunity Developmental processes Mesoderm development Hematopoiesis