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|Tested species reactivity||Mouse , Human , Rat , Primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human CSK expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15707 targets CSK in FACS, IF, and WB applications and shows reactivity with Human, mouse, Non-human primate, and Rat samples.
The MA5-15707 immunogen is purified recombinant fragment of human CSK expressed in E. Coli.
MA5-15707 detects CSK which has a predicted molecular weight of approximately 50kDa.
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-SRC kinase, protein-tyrosine kinase (CSK), tyrosine-protein kinase CSK, C-Src kinase, protein-tyrosine kinase CYL, MGC117393, CSK
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Intracellular signaling cascade Cell cycle Cell cycle control Cell proliferation and differentiation