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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (HCFRKHTDVFNWK) corresponding to the internal amino acids of TMPRSS4|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.3-1 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
TMPRSS4 correlates with colorectal cancer pathological stage and regulates cell proliferation and self-renewal ability.
PA5-18871 was used in immunohistochemistry - paraffin section and western blot to investigate the role of TMPRSS4 in colorectal cancer
|Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M||Cancer biology & therapy (15:297)||2014|
High expression level of TMPRSS4 predicts adverse outcomes of colorectal cancer patients.
PA5-18871 was used in immunohistochemistry to study the prognostic value of the immunohistochemical expression of TMPRSS4 in colorectal cancer
|Huang A,Zhou H,Zhao H,Quan Y,Feng B,Zheng M||Medical oncology (Northwood, London, England) (30:null)||2013|
CAPH2; Channel-activating protease 2; Membrane-type serine protease 2; MT-SP2; TMPRSS3; Transmembrane protease serine 4; transmembrane protease, serine 4; transmembrane serine protease 3; type II membrane serine protease
CAPH2; MT-SP2; TMPRSS3; TMPRSS4; UNQ776/PRO1570