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|Tested species reactivity||Virus|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant Nef protein of HIV-1 B-subtype consensus purified from E. coli|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody reacts with HIV-1 Nef subtypes A, B and C; JR-CSF, BRU, IIIB, LAV and BH10 strains. It has been mapped to amino acids 195-205 (ARELHPEYYKD – B subtype consensus).
HIV-1 Nef is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of receptor protein of the cell surface such as CD 4 and MH4, important for AIDS virus infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human immunodeficiency virus, HIV-1 Nef region 195-205, HIV1B