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|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Hairy cell leukaemia cells|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of acetone fixation for frozen sections. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The CD103 antigen is a 160-130-105 kDa molecule which is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. This human intra epithelial lymphocyte marker is the E integrin chain associated with the b7 subunit. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
MA5-16774 was used in flow cytometry to decipher how susequent acute infection is supressed in T cell responses after exposure to subinfectious hepatitis C virus
|Park SH,Veerapu NS,Shin EC,Biancotto A,McCoy JP,Capone S,Folgori A,Rehermann B||Nature medicine (19:1638)||2013|
|Not Applicable||Not Cited||
Higher proliferative capacity of T lymphocytes from patients with Crohn disease than from ulcerative colitis is disclosed by use of Herpesvirus saimiri-transformed T-cell lines.
MA5-16774 was used in flow cytometry to discuss the creation of stable T-cell lines to study their impact in inflammatory bowel disease
|Aguilera-Montilla N,Pérez-Blas M,Valeri AP,López-Santalla M,Rodríguez-Juan C,Mencía A,Castellano G,Manzano ML,Casis B,Sánchez F,Martín-Villa JM||Scandinavian journal of gastroenterology (39:1236)||2004|
|Not Applicable||Not Cited||
Intrinsic defects explain altered proliferative responses of T lymphocytes and HVS-derived T-cell lines in gastric adenocarcinoma.
MA5-16774 was used in flow cytometry to study T-cell lines from gastric cancer patients and healthy volunteers
|Valeri AP,Pérez-Blas M,Gutiérrez A,López-Santalla M,Aguilera N,Rodríguez-Juan C,Sala-Silveira L,Martín J,Lasa I,Mugüerza JM,López A,García-Sancho L,Granell J,Martín-Villa JM||Cancer immunology, immunotherapy : CII (52:708)||2003|
Phenotypic and molecular characterization of CD103+ CD4+ T cells in bronchoalveolar lavage from patients with interstitial lung diseases.
MA5-16774 was used in flow cytometry to test if CD103 has a regulatory role in the microenvironment of the epithelial cell layer.
|Braun RK,Foerster M,Grahmann PR,Haefner D,Workalemahu G,Kroegel C||Cytometry. Part B, Clinical cytometry (54:19)||2003|
alpha polypeptide; antigen CD103; antigen CD103, human mucosal lymphocyte antigen 1; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; CD103, HUMINAE,HML-1 antigen; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; integrin alpha E; Integrin alpha-E; Integrin alpha-IEL; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); Mucosal lymphocyte 1 antigen
CD103; HUMINAE; ITGAE