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|Tested species reactivity||Mouse , Human , Rat , Sheep|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (A.A. 12-18: CRLWRSRAPGGEDEEEGAG and A.A. 36-50 CELRGEGATDSRAHGA) of SMAD7/MADH7 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||2-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily (1). SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, 2, 5, 8 and 9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MAD homolog 7, MAD homolog 8, SMAD 7, madh8, mothers against DPP homolog 7, mothers against DPP homolog 8, mothers against decapentaplegic homolog 7, mothers against decapentaplegic homolog 8, MAD (mothers against decapentaplegic, Drosophila) homolog 7, Mothers against decapentaplegic, drosophila, homolog of, 7, SMAD, mothers against DPP homolog 7, hSMAD7, CRCS3, MADH7, MADH8, MAD (mothers against decapentaplegic, Drosophila) homolog 7, Mothers against decapentaplegic, drosophila, homolog of, 7, SMAD
CRCS3, MADH7, Madh7, MADH8
Nucleoside, nucleotide and nucleic acid metabolism mRNA transcription mRNA transcription regulation Signal transduction Cell surface receptor mediated signal transduction Receptor protein serine/threonine kinase signaling pathway Intracellular signaling cascade Other intracellular signaling cascade Cell communication Ligand-mediated signaling Immunity and defense Stress response Oncogenesis Developmental processes