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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, Kappa|
|Immunogen||Synthetic peptide (68 DFEYLEIRQLETQADPTGR 86) of MyD88 protein.|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5 µg/10^6 cells|
|Immunocytochemistry (ICC)||5 µg/ml|
|Immunofluorescence (IF)||5 µg/ml|
|Western Blot (WB)||5-7 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy.
MA5-16231 was used in immunohistochemistry to study the prognostic significance of TLR8 expression in patients with enterovirus-associated dilated cardiomyopathy
|Satoh M,Akatsu T,Ishikawa Y,Minami Y,Takahashi Y,Nakamura M||American heart journal (154:581)||2007|
mutant myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88