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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2A|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human IL-27 Arg21-Lys229 of EBI-3 and Phe29-Pro243 of p28|
|Storage buffer||Buffered saline solution with BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10 µl/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EBV-induced gene 3 protein, Epstein-Barr virus induced gene 3, IL-27 subunit beta, IL27 subunit, IL35 subunit, cytokine receptor, epstein-Barr virus-induced gene 3 protein, IL-27 p28 subunit, IL-27 subunit alpha, IL-27-A, IL27-A, interleukin 30, interleukin-30, IL27, EBI3, IL-27A, IL27A, IL27 p28, IL30, interleukin-27 subunit alpha, IL-27B, IL27B
IL27A, IL27B, IL30, IL-27B, IL-27A, p28, IL-27, IL27p28
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Intracellular signaling cascade JAK-STAT cascade Cell communication Ligand-mediated signaling Developmental processes Ectoderm development Neurogenesis Biological process unclassified