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|Tested species reactivity||Horse , Rabbit , Cattle|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Lysed bovine corneal endothelial cells and extracellular matrix.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CSI 004-18-02 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). CSI 004-18-02 cross-reacts with rabbit and horse vitronectin, no reactivity with human or sheep.
CSI 004-18-02 has been successfully used in ELISA and Immunohistochemistry techniques. CSI 004-18-02 is suitable in ELISA and immunostaining of frozen PLP-fixed sections of bovine tissues.
The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation.
CSI 004-18-02 reacts weakly in ELISA with vitronectin coated directly onto the microtiter plate.
The CSI 004-18-02 immunogen is lysed bovine corneal endothelial cells and extracellular matrix.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/ml
Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognises fibronectin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
S-protein, glycoprotein 66, serum-spreading factor, vitronectin, vitronectin (serum spreading factor, somatomedin B, complement S-protein), Serum spreading factor, Complement S Protein, Epibolin, S Protein, Somatomedin B antibody, VTN