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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Immunogen||Mouse pre-B tumour cells.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 ug/1 million cells|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-70098 detects CD45R in mouse samples.
MA1-70098 has been successfully used in flow cytometry, immunoprecipitation and immunohistochemistry procedures.
The MA1-70098 immunogen is mouse pre-B tumour cells.
CD45R is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Generation of eosinophils from cryopreserved murine bone marrow cells.
MA1-70098 was used in flow cytometry to develop a culture system to grow functional eosinophils from bone marrow progenitors
|Schollaert KL,Stephens MR,Gray JK,Fulkerson PC||PloS one (9:null)||2015|
T cells generated in the absence of a thoracic thymus fail to establish homeostasis.
MA1-70098 was used in flow cytometry to investigate the role of thoracic thymus in T cell development and homeostasis
|Smolarchuk C,Zhu LF,Chan WF,Anderson CC||European journal of immunology (44:2263)||2014|
Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid.
MA1-70098 was used in flow cytometry to study the effect of dietary cis-9, trans- and trans-0, cis-2 conjugated linoleic acid on immunoglobulin and cytokine production from spleen lymphocytes in C57BL/6J mice.
|Yamasaki M,Chujo H,Hirao A,Koyanagi N,Okamoto T,Tojo N,Oishi A,Iwata T,Yamauchi-Sato Y,Yamamoto T,Tsutsumi K,Tachibana H,Yamada K||The Journal of nutrition (133:784)||2003|
Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome.
MA1-70098 was used in immunohistochemistry - paraffin section to test a gene therapy treatment for Wiskott-Aldrich syndrome for clinical efficacy and safety.
|Bosticardo M,Draghici E,Schena F,Sauer AV,Fontana E,Castiello MC,Catucci M,Locci M,Naldini L,Aiuti A,Roncarolo MG,Poliani PL,Traggiai E,Villa A||The Journal of allergy and clinical immunology (127:1376)||2011|
Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity.
MA1-70098 was used in flow cytometry to study regulation of the lck in T cell lineage commitment.
|Shimizu C,Kawamoto H,Yamashita M,Kimura M,Kondou E,Kaneko Y,Okada S,Tokuhisa T,Yokoyama M,Taniguchi M,Katsura Y,Nakayama T||International immunology (13:105)||2001|
Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand.
MA1-70098 was used in flow cytometry to study FasL expression on thyrocytes.
|Batteux F,Tourneur L,Trebeden H,Charreire J,Chiocchia G||Journal of immunology (Baltimore, Md. : 1950) (162:603)||1999|
Continued differentiation during B lymphopoiesis requires signals in addition to cell survival.
MA1-70098 was used in flow cytometry to study the contribution of Ig heavy chain-containing receptors on B cell development.
|Tarlinton DM,Corcoran LM,Strasser A||International immunology (9:1481)||1997|
B220; Cd45; CD45R; Cluster designation 45R; leukocyte common antigen; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; receptor-type tyrosine-protein phosphatase C
B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; T200