|Flow Cytometry (Flow)||1-2 ug/ml|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody recognizes the N-terminal part of ABRA1 (Abraxas, CCDC98), which migrates as a 45 kDa band on PAAGE under reducing conditions.
ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABRA1; abraxas protein; BRCA1-A complex subunit Abraxas; CCDC98; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; UNQ496/PRO1013
Gene Aliases: ABRA1; CCDC98; FAM175A; UNQ496/PRO1013
UniProt ID: (Human) Q6UWZ7
Entrez Gene ID: (Human) 84142
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