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Neutralization assay of recombinant mouse IL-11 stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by recombinant mouse IL-11 (0.3 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-mouse IL-11 Ra Antigen Affinity-purified Polyclonal Antibody (Product # PA5-47667). The ND50 is typically 2-6 µg/mL.
|Tested species reactivity||Mouse|
|Host / Isotype||Goat / IgG|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant mouse IL-11 R alpha Ser22-Gln367|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 5% trehalose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Neutralization (Neu)||2-6 µg/ml|
|Western Blot (WB)||0.1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL-11 receptor subunit alpha-1, IL-11R subunit alpha-1, IL-11R-alpha-1, IL-11RA1, Il-11ra-alpha, NR-1, enhancer trap locus homolog 2, etl-2, interleukin 11 receptor, alpha chain 2, interleukin-11 receptor subunit alpha-1, locus 2, novel cytokine receptor 1, IL11RA, AI314697, IL-11RA, Il11ra2, NR1
AI314697, GP130, Il11ra, Il-11ra, Il11ra2, NR1
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Intracellular signaling cascade MAPKKK cascade JAK-STAT cascade Cell communication Ligand-mediated signaling Immunity and defense Developmental processes Mesoderm development Hematopoiesis