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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from the middle region of human MMP-9|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-29187 detects MMP9 from human samples.
PA1-29187 has been successfully used in immunoprecipitation and Western blot applications. A suggested positive control for this product is conditioned, serum free medium from (TPA-treated) human fibrosarcoma HT-1080 cells.
The PA1-29187 immunogen is synthetic peptide from the middle region of human MMP-9.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
92 kDa gelatinase, 92 kDa type IV collagenase, macrophage gelatinase, matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), matrix metalloproteinase-9, type V collagenase, CLG4B, GELB, MANDP2, MMP-9
MANDP2, GELB, MMP-9, CLG4B