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|Tested species reactivity||Dog , Human , Porcine , Cat , Primate|
|Published species reactivity||Porcine|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human TNF alpha from Pichia pastoris.|
|Storage buffer||PBS with 10% trehalose|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
M3TNFAI targets TNF Alpha in ELISA, and WB applications and shows reactivity with Canine, Feline, Human, Non-human primate, and Porcine samples.
The M3TNFAI immunogen is recombinant human TNF alpha from Pichia pastoris.
M3TNFAI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression of inflammatory markers in pig amnion after intraamniotic infection with nonpathogenic or enteropathogenic Escherichia coli.
M3TNFAI was used in immunohistochemistry to study the expression of inflammatory markers in pig amnion after intraamniotic infection with nonpathogenic or enteropathogenic Escherichia coli
|Splíchalová A,Splíchal I,Trebichavský I,Hojná H||Folia microbiologica (49:751)||2005|
APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha, TNF-alpha, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, tumor-necrosis factor, tumour necrosis factor, TNF superfamily, member 2
DIF, TNFSF2, TNFA, TNFa, SBAB-548A10.2, TNF-alpha, cTNF, DADB-70P7.1
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Cell communication Ligand-mediated signaling Immunity and defense Apoptosis Induction of apoptosis