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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 14 amino acid peptide from N-terminal extracellular domain of human MRGPRX1 / MRGX1.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||12 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Percent identity with other species by BLAST analysis: Human, Monkey (100%) Gibbon (93%).
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; Mas-related G protein-coupled receptor G2; MAS-related GPR; MAS-related GPR, member X1; member X1; MRGPRX1; MRGX1; sensory neuron-specific G-protein coupled receptor 3/4; SNSR3; SNSR4
GPCR; MGRG2; MRGPRX1; MRGX1; SNSR3; SNSR4