Immunohistochemical analysis of MYD88 in paraffin embedded Human Tonsil. Steamed antigen retrieval with Tris / EDTA buffer pH 9 was performed, followed by application of the MYD88 antibody (Product # PA1-9072) (4µg / ml) and HRP-staining. These results could not been obtained after antigen retireval at pH6 with this batch of antibody.
|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Internal sequence corresponding to amino acids C-IKYKAMKKEFP.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-6µg/ml|
|Western Blot (WB)||0.1-0.3 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
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