|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS, pH 7.2|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:100|
|Immunohistochemistry (Frozen) (IHC (F))||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-7629 detects p53 from human, rat and mouse samples.
MA1-7629 has been successfully used in ELISA, fluorescent microscopy, flow cytometry, immunoprecipitation and immunohistochemistry (frozen) procedures.
The MA1-7629 immunogen is a p53 protein.
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The effect of vitamin C administration on monosodium glutamate induced liver injury. An experimental study.
MA1-7629 was used in immunohistochemistry to study the ability of vitamin C to protect against liver injury induced by monosodium glutamate
|El-Meghawry El-Kenawy A,Osman HE,Daghestani MH||Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (65:513)||2013|
The effects of PDE5 inhibitory drugs on renal ischemia/reperfusion injury in rats.
MA1-7629 was used in immunohistochemistry to study the effects of the PDE5 inhibitors Tadalfil and Sildenafil on rat renal ischemia/reperfusion injury
|Küçük A,Yucel M,Erkasap N,Tosun M,Koken T,Ozkurt M,Erkasap S||Molecular biology reports (39:9775)||2012|
Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity.
MA1-7629 was used in immunohistochemistry to investigate the protective effect of coenzyme Q10 against acetaminophen toxicity in rat liver
|Fouad AA,Jresat I||Environmental toxicology and pharmacology (33:158)||2012|
Protective effects of doxycycline in ischemia/reperfusion injury on kidney.
MA1-7629 was used in immunohistochemistry to study the ability of doxycycline to protect the kidney from ischemia/reperfusion injury
|Kucuk A,Kabadere S,Tosun M,Koken T,Kinaci MK,Isikli B,Erkasap N||Journal of physiology and biochemistry (65:183)||2009|
Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation.
MA1-7629 was used in immunohistochemistry to study the consequences of mouse small intestine Chk1 deficiency
|Greenow KR,Clarke AR,Jones RH||Oncogene (28:1443)||2009|
Immunohistochemical study of proteins linked to apoptosis in rat fetal kidney cells following prepregnancy adriamycin administration in the mother.
MA1-7629 was used in immunohistochemistry to study the expression of proteins involved in apoptosis in rat fetal kidney cells following maternal prepregnancy adriamycin administration
|Pedrycz A,Czerny K||Acta histochemica (110:519)||2008|
p53 Expression and apoptosis in liver and spleen during CO2 pneumoperitoneum.
MA1-7629 was used in immunohistochemistry to study to study the effects of CO2 pneumoperitoneum on p53 expression and apoptosis in liver and spleen
|Arikan Y,Tosun M,Saykol V,Kalkan S,Erdem S||Langenbeck's archives of surgery / Deutsche Gesellschaft fu¿r Chirurgie (393:877)||2008|
X-irradiation reduces the proliferation of astrocytes by cell cycle arrest.
MA1-7629 was used in western blot to study the mechanism by which X-ray irradiation attenuates the proliferation of astrocytes
|Wang Q,Xu Y,Xie MJ,Yu ZY,Qin YY,Wang W,Zhu Z||Neuroscience letters (498:78)||2011|