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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant, full-length mouse p18INK4c|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis.
39-3400 was used in western blot to use transgenic mice to show that CDK5 activity is crucial for cell cycle progression and medullary thyroid carcinoma proliferation.
|Pozo K,Hillmann A,Augustyn A,Plattner F,Hai T,Singh T,Ramezani S,Sun X,Pfragner R,Minna JD,Cote GJ,Chen H,Bibb JA,Nwariaku FE||Oncotarget (6:12080)||2015|
CDK6 inhibitor p18, cyclin-dependent inhibitor, cyclin-dependent kinase 4 inhibitor C, cyclin-dependent kinase 6 inhibitor p18, p18-INK6, cyclin-dependent kinase 6 inhibitor, INK4C, p18-INK4C
RP11-278J17.2, p18INK4c, p18-INK4C, p18-INK4c, p18, p18-INK6, C77269, INK4C, INK4c