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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||NS0 mouse myeloma cell line transfected with human ICOS and mouse myeloma cell line NS0-derived recombinant human ICOS cocktail Glu21-Phe141|
|Storage buffer||Buffered saline solution with BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10 µl/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell co-stimulator; Inducible T-cell costimulator
AILIM; CD278; CVID1; ICOS