|Immunohistochemistry (Paraffin) (IHC (P))||9.3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from 2nd extracellular domain of human MRGPRD.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Gibbon, Monkey (94%).
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD; Mas-related G-protein coupled receptor member D; MAS-related GPR; MAS-related GPR, member D; member D; MRGD; MRGPRD; TGR7
Gene Aliases: MRGD; MRGPRD; TGR7
UniProt ID: (Human) Q8TDS7
Entrez Gene ID: (Human) 116512
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