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|Tested species reactivity||Mouse|
|Published species reactivity||Rat , Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and 92% homologous to human sequence.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||2-4 ug/ml|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.
488100 was used in immunohistochemistry to identify mechanisms of Panx activation.
|Weilinger NL,Tang PL,Thompson RJ||The Journal of neuroscience : the official journal of the Society for Neuroscience (32:12579)||2012|
Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.
488100 was used in immunohistochemistry - frozen section and western blot to discuss the role of NLRP/NALP during central nervous system injury.
|Mawhinney LJ,de Rivero Vaccari JP,Dale GA,Keane RW,Bramlett HM||BMC neuroscience (12:null)||2012|
pannexin-1, PANX1, Pannexin 1, Pannexin-1, PX1, MRS1, UNQ2529, UNQ2529/PRO6028