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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||PBS with 0.1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:50|
|Functional Assay (FN)||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-40034 detects CD180 from mouse samples.
MA1-40034 has been successfully used in flow cytometry and funtional applications.
The MA1-40034 immunogen is mouse RP105/CD180.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD180 antigen, ly-78, lymphocyte antigen 78, radioprotective 105 kDa protein, LY64, Ly78, lymphocyte antigen 64, lymphocyte antigen-64 radioprotective
RP105, Ly78, F630107B15
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Immunity and defense T-cell mediated immunity Granulocyte-mediated immunity Macrophage-mediated immunity