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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 430-445 of the NC3 region of human and mouse CLAC-P.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5-10 ug/ml|
|Western Blot (WB)||2-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-10881 detects CLAC-P in human and mouse samples.
PA1-10881 has been successfully used in Western blot and immunohistochemistry (paraffin embedded sections) procedures. A band of approximately 70 kDa is detected by Western blot in HEK293 cell lysate.
PA1-10881 immunogen is a synthetic peptide corresponding to residues 430-445 of the NC3 region of human and mouse CLAC-P.
Alzheimer"e;s disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Alzheimer disease amyloid-associated protein; AMY; CLAC; CLAC-P; CLACP; col25a1; Collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
2700062B08Rik; AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1