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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid synthetic peptide near the amino terminus of human EED|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||20 ug/mL|
|Western Blot (WB)||1 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is human heart tissue lysate.
PA5-34430 can be used with blocking peptide PEP-1472.
The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EED; Embryonic ectoderm development; HEED; lethal, Chr 7, Rinchik 5; Polycomb protein EED; WAIT-1; WAIT1; WD protein associating with integrin cytoplasmic tails 1
EED; ENSMUSG00000039373; HEED; l(7)5Rn; l7Rn5; lusk; WAIT1