|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid peptide near the amino terminus of human TYK2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1 - 2 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
A suggested positive control is human small intestine tissue lysate.
PA5-34497 can be used with blocking peptide PEP-1539.
TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.
PA5-34497 was used in western blot to study the effects of HDAC6 modulation using antigen presenting cells
|Cheng F,Lienlaf M,Wang HW,Perez-Villarroel P,Lee C,Woan K,Rock-Klotz J,Sahakian E,Woods D,Pinilla-Ibarz J,Kalin J,Tao J,Hancock W,Kozikowski A,Seto E,Villagra A,Sotomayor EM||Journal of immunology (Baltimore, Md. : 1950) (193:2850)||2014|