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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2B|
|Immunogen||CHO cell-derived recombinant mouse IL-27 (aa 29-234 of p28, aa 19-228 of EBI-3)|
|Storage buffer||Buffered saline solution with BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody recognizes the p28 subunit either as part of a p28/EBI-3 heterodimer or as a free subunit.
Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
EBI3; Epstein-Barr virus-induced gene 3 protein homolog; IL-27 p28 subunit; IL-27 subunit alpha; IL-27 subunit beta; IL-27-A; IL-27A; IL-27B; IL27; IL27 p28; IL27-A; IL27A; IL27B; IL30; interleukin 30; Interleukin-27 subunit alpha; Interleukin-27 subunit beta; p28
EBI-3; Ebi3; IL-27; IL-27p28; Il27; Il27a; Il27b; Il30; p28