|Flow Cytometry (Flow)||Assay-Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2B|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant mouse IL-27 heterodimer Tyr19-Pro228 (EBI3) and Phe29-Ser234 (p28)|
|Storage buffer||Buffered saline solution with BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, store in dark|
This antibody recognizes the p28 subunit either as part of a p28/EBI-3 heterodimer or as a free subunit.
Interleukin 27, or IL-27 is a cytokine belonging to the IL-12 family. It is a heterodimeric cytokine composed of EBI3 and p28 subunits. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines. IL-27 promotes CD4+ T cell differentiation to the Th1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12R beta2, which in turn suppresses Th2 and Th17 differentiation and proliferation. In humans, the gene is located on the p arm of chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EBI3; Epstein-Barr virus-induced gene 3 protein homolog; IL-27 p28 subunit; IL-27 subunit alpha; IL-27 subunit beta; IL-27-A; IL-27A; IL-27B; IL27; IL27 p28; IL27-A; IL27A; IL27B; IL30; interleukin 30; Interleukin-27 subunit alpha; Interleukin-27 subunit beta; p28
Gene Aliases: EBI-3; Ebi3; IL-27; IL-27p28; Il27; Il27a; Il27b; Il30; p28
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