|Immunohistochemistry (Paraffin) (IHC (P))||8 - 21 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GIPR.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
BLAST analysis of the peptide immunogen showed 100% homology with human protein GHRHR.
Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%) Marmoset (95%) Dog, Hamster, Panda (89%) Mouse, Rat, Rabbit (84%).
Gastric inhibitory polypeptide (GIP; MIM 137240), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; GIPR; Glucose-dependent insulinotropic polypeptide receptor; PGQTL2
Gene Aliases: GIPR; PGQTL2
UniProt ID: (Human) P48546
Entrez Gene ID: (Human) 2696
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