|Tested species reactivity||Bovine, Dog, Chicken, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (661 GAKQASSQSWVPG 673) of FOXO3A/FKHRL1 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
FOXO3A belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOXO3A is an embryonic transcriptional regulator involved in erythropoiesis and plays an important role in the cell cycle of megakaryocytic cells. It also has a critical role in regulation of proliferation, control of oxidative stress and triggers apoptosis by inducing the expression of genes such as the Fas ligand gene TNFSF6. It is also known to regulate cardiac myocyte size downstream of AKT signaling. FOXO3A promotes DNA repair under low stress conditions and a program of cell death under higher level of stress thus protecting quiescent cells from oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.