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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T187 of human MAP3K7|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Dot blot (DB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.
MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
TGF-beta activated kinase 1, TGF-beta-activated kinase 1, mitogen-activated protein kinase kinase kinase 7, transforming growth factor-beta-activated kinase 1, TAK1
MEKK7, TGF1a, RP1-154G14.1, TAK1
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Intracellular signaling cascade MAPKKK cascade JNK cascade Immunity and defense Developmental processes Embryogenesis Apoptosis Cell structure and motility Cell structure