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|Tested species reactivity||Horse , Human , Mouse , Rat , Cattle , Dog , Porcine , Rabbit|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide directed towards the C-terminal of human MAK|
|Storage buffer||PBS with 2% sucrose|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Peptide sequence: WNTKTGRGQF SGRTYNPTAK NLNIVNRAQP IPSVHGRTDW VAKYGGHR
Sequence homology: Cow: 93%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
protein kinase RCK, serine/threonine-protein kinase MAK, male germ cell-associated kinase retinal-enriched isoform, serine/threonine protein kinase MAK, dJ417M14.2
dJ417M14.2, RP3-417M14.2, A930010O05Rik, RP62
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Intracellular signaling cascade Other intracellular signaling cascade Developmental processes Gametogenesis Spermatogenesis and motility