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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Sheep|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to 16 residues near the middle of human TLR8.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||2 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Western Blot (WB)||0.5 - 2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
A suggested positive control for this product is Daudi cell lysate.
Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway.. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Involvement of TLR7 and TLR8 in conceptus development and establishment of pregnancy in sheep.
PA1-12830 was used in immunohistochemistry - paraffin section to study TLR signaling during ovine pregnancy
|Ruiz-González I,Minten M,Wang X,Dunlap KA,Bazer FW||Reproduction (Cambridge, England) (149:305)||2015|
toll-like receptor 8, Toll-like Receptor 8, CD antigen 288, UNQ249/PRO286
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Receptor protein serine/threonine kinase signaling pathway Immunity and defense T-cell mediated immunity Granulocyte-mediated immunity Macrophage-mediated immunity Developmental processes