|Immunohistochemistry (Frozen) (IHC (F))||1:100-1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
|Immunohistochemistry (IHC)||See 3 publications below|
|Tested Species reactivity||Virus|
|Published species reactivity||Virus Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant fusion protein of bacterial beta-galactosidase and EBV LMP-1|
|Storage buffer||tissue culture supernatant|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase.
Prior to reconstitution, store at 4°C. Reconstitute with 1 ml of distilled water. After reconstitution, store undiluted at -20°C, avoiding freeze/thaw cycles.
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EBV; EBV Latent membrane protein
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