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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2B|
|Immunogen||Mouse myeloma cell line NS0-derived recombinant human Carbonic AnhydraseXIV/CA14 Gly19-Met290|
|Storage buffer||PBS with 5% trehalose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||25 µg/ml|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse CA14, 10% cross-reactivity with recombinant human (rh) CA5A, and no cross-reactivity with rhCA1, 2, 3, 4, 6, 7, 8, 9, 10, 12, or 13 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII, however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CA-XIV, carbonate dehydratase XIV, carbonic anhydrase 14, carbonic dehydratase, CAXiV