|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2a|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-17852 targets CD40/Bp50 in FACS and IHC (F) applications and shows reactivity with Mouse samples.
The MA5-17852 immunogen is mouse CD40.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Purified eicosapentaenoic acid induces prolonged survival of cardiac allografts and generates regulatory T cells.
MA5-17852 was used in flow cytometry to test if eicosapentaenoic acid treatment alters the survival of fully mismatched murine cardiac allografts
|Iwami D,Zhang Q,Aramaki O,Nonomura K,Shirasugi N,Niimi M||American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (9:1294)||2009|
|Not Applicable||Not Cited||
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
MA5-17852 was used in flow cytometry to clone and characterize Siglec-H
|Zhang J,Raper A,Sugita N,Hingorani R,Salio M,Palmowski MJ,Cerundolo V,Crocker PR||Blood (107:3600)||2006|
Activation of dendritic cells and induction of T cell responses by HPV 16 L1/E7 chimeric virus-like particles are enhanced by CpG ODN or sorbitol.
MA5-17852 was used in flow cytometry to study the interaction of human papillomavirus 16 L1/E7 chimeric virus-like particles with mouse bone marrow-derived dendritic cells activated with different immune adjuvants
|Freyschmidt EJ,Alonso A,Hartmann G,Gissmann L||Antiviral therapy (9:479)||2004|
Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice.
MA5-17852 was used in flow cytometry to assess the contribution of DC function in non-obese diabetic mice.
|Morin J,Faideau B,Gagnerault MC,Lepault F,Boitard C,Boudaly S||Clinical and experimental immunology (134:388)||2003|
Uptake and presentation of antigen to T cells by primary colonic epithelial cells in normal and diseased states.
MA5-17852 was used in flow cytometry to determine the immunoregulatory properties of primary colonic epithelial cells.
|Telega GW,Baumgart DC,Carding SR||Gastroenterology (119:1548)||2000|
Dendritic cells in the induction of protective and nonprotective anticryptococcal cell-mediated immune responses.
MA5-17852 was used in flow cytometry to examine the contribution of different DC subsets during infection with Cryptococcus neoformans.
|Bauman SK,Nichols KL,Murphy JW||Journal of immunology (Baltimore, Md. : 1950) (165:158)||2000|