|Flow Cytometry (Flow)||1-2 µg/test|
|Flow Cytometry (Flow)||See 6 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human TCR Vdelta1-Jdelta2|
|Storage buffer||PBS with glycerol, 0.5% BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
TCR2055 targets TCR Delta TCS1 in FACS applications and shows reactivity with Human samples.
The TCR2055 immunogen is human TCR Vdelta1-Jdelta2.
TCR2055 detects TCR Delta TCS1 which has a predicted molecular weight of approximately 127 kDa.
Washing step with 0.1% Tween is necessary to expose antigen.
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: telomerase catalytic subunit; telomerase-associated protein 2, TCRdv1
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