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|Tested species reactivity||Non-human primate, Bovine, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (614 HEESPFEKQFKRRSC 628) of DUSP16/MKP7 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
DUSP16 is a 665 amino acid novel mitogen-activated protein kinase phosphatase belonging to the non-receptor class of the protein-tyrosine phosphatase family with a rhodanese-like domain, protein tyrosine phosphatase catalytic domain and a long terminal stretch containing nuclear export and localization signal. DUSP16 are dual-specificity phosphatases that dephosphorylate the TXY motif of MAPK TXY motifs, thereby inactivating MAP kinases. DUSP16 is ubiquitously expressed and behaves both as a nuclear shuttle and as a phosphatase. It binds to and inactivates p38 MAPK and JNK/SAPK, p38 alpha and –beta but not gamma or delta and ERK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAP kinase phosphatase-7; map kinase phosphatase-M; MAPK phosphatase-7; Mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7
3830417M17Rik; AW558566; D6Ertd213e; DUSP16; KIAA1700; MKP-7; MKP7; Mkpm