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|Tested species reactivity||Bovine, Human, Non-human primate, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified bovine Tau|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
MN1010B targets Tau in ELISA and WB applications and shows reactivity with Bovine, Human, Non-human primate, and Rat samples.
The MN1010B immunogen is purified bovine Tau.
MN1010B detects Tau which has a predicted molecular weight of approximately 79 kDa.
Paired helical filament (PHF) is a major component of the neurofibrillary tangles involved in the pathology of Alzheimer"e;s disease. PHFs are composed of the microtubule-associated protein tau in a hyper-phosphorylated state (ref1). Tau protein is produced by a single gene expressed predominantly in neurons. The Tau gene undergoes complex alternative splicing, yielding six different isoforms of tau in the adult brain. Following translation, the tau protein can be further modified by phosphorylation at several different sites
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats.
MN1010B was used in western blot to study mitochondrial function, autophagy and phosphorylated tau in type 1 diabetic rat cerebral cortex and the effects of insulin treatment
|Santos RX,Correia SC,Alves MG,Oliveira PF,Cardoso S,Carvalho C,Duarte AI,Santos MS,Moreira PI||Biochimica et biophysica acta (1842:1154)||2014|
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
MN1010B was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead
|Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S||Acta biologica Hungarica (63:411)||2012|
G protein beta1/gamma2 subunit-interacting factor 1; microtubule associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; protein phosphatase 1, regulatory subunit 103; Tau microtubule-associated protein
BOS_19251; DDPAC; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; pTau; RNPTAU; TAU