|Immunohistochemistry (Paraffin) (IHC (P))||5 - 7.5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from near C-terminus of human BEST3.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Marmoset, Mouse, Rat, Hamster (89%) Monkey, Bat (83%).
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BEST3; Bestrophin 3; Bestrophin-3; vitelliform macular dystrophy 2-like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3
Gene Aliases: BEST3; VMD2L3
UniProt ID: (Human) Q8N1M1
Entrez Gene ID: (Human) 144453
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