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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein encoding 26-176 aa of human CD105|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.
Endoglin, also called CD105, is a homodimeric membrane glycoprotein primarily associated with human vascular endothelium. It is also found on bone marrow proerythroblasts, activated monocytes, and lymphoblasts in childhood leukemia. Endoglin is a component of the transforming growth factor beta receptor complex, as it binds TGFB1 with high affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
18F-FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas: correlation with histopathology.
PA1-37372 was used in immunohistochemistry - frozen section to correlate (18)F-FB-mini-PEG-E[c(RGDyK)](2) ((18)F-FPRGD2) uptake to integrin alphavbeta3 expression and angiogenesis in renal tumors
|Withofs N,Signolle N,Somja J,Lovinfosse P,Nzaramba EM,Mievis F,Giacomelli F,Waltregny D,Cataldo D,Gambhir SS,Hustinx R||Journal of nuclear medicine : official publication, Society of Nuclear Medicine (56:361)||2015|
CD105; CD105 antigen; END; Endoglin; ENG; HHT1; ORW; ORW1
END; ENG; HHT1; ORW1