|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||H-2Kb - specific mouse cytotoxic T lymphocyte clone BM10-37.|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Neat-1:5|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
For FACS analysis, use 5ul of the suggested working dilution to label 1x10^6 cells in 100ul.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells.
MA5-16449 was used in flow cytometry to characterize the expression and function of 4-1BBL.
|Futagawa T,Akiba H,Kodama T,Takeda K,Hosoda Y,Yagita H,Okumura K||International immunology (14:275)||2002|