|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Tested Species reactivity||Horse, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (109 LDLSHNQLTECPRELENAK 127) of FLII protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
FLII (Flightless-1 homolog, FLIIH) is a 1269 amino acid containing protein with a gelsolin-like actin binding domain and an N-terminal leucine rich protein-protein interaction domain acts as a coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and in conjunction with NCOA2 and CARM1. FLII is involved in estrogen hormone signaling and early embryonic development. The protein also plays a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLI; Fli1; flightless I actin binding protein; flightless I homolog; FLIL; Protein flightless-1 homolog
Gene Aliases: 3632430F08Rik; FLI; Fli1; FLII; Fliih; FLIL
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