|Flow Cytometry (Flow)||5 ul for 1x10^6 cells|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
Mouse anti-rat CD61, clone F11, recognizes both human and rat CD61 antigen.
Use dim light during handling, incubation with cells, and prior to analysis. It is recommended that cells be analyzed within 18 hours of staining. If the reagent is being diluted, it is recommended that only the quantity to be used within one week be diluted.
The ITGB3 protein product is the integrin beta 3 chain (CD61). Integrins are integral cell-surface proteins and are known to participate in cell adhesion as well as cell-surface mediated signaling. Integrins are composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the integrin alpha IIb chain (CD41) on platelets and megakaryocytes, and is also known as the vitronectin receptor. The vitronectin receptor mediates cellular adhesion to vitronectin, fibrinogen, fibronectin, thrombospondin, and von Willebrand Factor1. On myeloid and endothelial cells, and osteoclasts, CD61 is associated with the integrin alpha v chain (CD512).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD61; BDPLT2; CD61; GP3A; GPIIIa; integrin beta 3; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Aliases: BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; ITGB3
UniProt ID: (Human) P05106
Entrez Gene ID: (Human) 3690
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