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|Tested species reactivity||Mouse , Human , Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic non-phosphopeptide derived from human TUBA1/3/4 around the phosphorylation site of Tyr272 (A-T-YP-A-P)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The microtubules are intracellular dynamic polymers made up of evolutionarily conserved polymorphic alpha/beta-tubulin heterodimers and a large number of microtubule-associated proteins (MAPs). Microtubules have their intrinsic polarity; highly dynamic plus ends and less dynamic minus ends. Microtubules are required for vital processes in eukaryotic cells including mitosis, meiosis, maintenance of cell shape and intracellular transport. Microtubules are also necessary for movement of cells by means of flagella and cilia. In mammalian tissue culture cells microtubules have their minus ends anchored in microtubule organizing centers (MTOCs).The GTP (guanosintriphosphate) molecule is an essential for tubulin heterodimer to associate with other heterodimers to form microtubule. In vivo, microtubule dynamics vary considerably. Microtubule polymerization is reversible and a populations of microtubules in cells are on their minus ends either growing or shortening - this phenomenon is called dynamic instability of microtubules. The alpha-tubulin (relative molecular weight around 50 kDa) is globular protein that exists in cells as part of soluble alpha/beta-tubulin dimer or it is polymerized into microtubules. In different species it is coded by multiple tubulin genes that form tubulin classes (in human 6 genes).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha-tubulin 2, tubulin alpha-1B chain, tubulin alpha-2 chain, alpha-tubulin isotype M-alpha-2, tubulin, alpha 2, hum-a-tub1, hum-a-tub2, tubulin B-alpha-1, tubulin alpha-1A chain, tubulin alpha-3 chain, tubulin, alpha, brain-specific, tubulin H2-alpha, tubulin alpha-1 chain, tubulin alpha-4A chain, tubulin, alpha 1 (testis specific), alpha-tubulin 6, alpha-tubulin isotype M-alpha-6, tubulin alpha-1C chain, tubulin alpha-6 chain, tubulin, alpha 6, alpha-tubulin 1, tubulin, alpha 1, alpha-tubulin 4, alpha-tubulin isotype M-alpha-4, tubulin alpha-4 chain, tubulin, alpha 4, Talpha1 alpha-tubulin, alpha-tubulin isotype M-alpha-1, alpha-tubulin isotype H2-alpha, tubulin alpha-3C/D chain, alpha-tubulin 3E, tubulin alpha-3E chain, alpha tubulin, alpha-tubulin ubiquitous, tubulin K-alpha-1, tubulin alpha-ubiquitous chain, tubulin, alpha, ubiquitous, TUBA1/3/4, H2-ALPHA, TUBA1, tubulin, alpha 1, B-ALPHA-1, LIS3, TUBA3, alpha-tubulin 3, alpha 3, alpha, brain-specific
Tuba6, Tuba4, Tuba2, RGD1565476, Tuba1, M[a]6, M[a]4, K-ALPHA-1, B-ALPHA-1, TUBA6, bcm948, Tuba-1, TUBA3, H2-ALPHA, TUBA1, LIS3
(Human) Q71U36, (Human) P68363, (Human) Q9BQE3, (Human) Q13748, (Human) Q6PEY2, (Human) P68366, (Mouse) P68369, (Rat) P68370, (Mouse) P05213, (Rat) Q6P9V9, (Mouse) P68373, (Rat) Q5XIF6, (Mouse) P68368
(Human) 7846, (Human) 10376, (Human) 84790, (Human) 113457, (Human) 112714, (Human) 7277, (Mouse) 22142, (Rat) 64158, (Mouse) 22143, (Rat) 500929, (Rat) 300218, (Mouse) 22146, (Rat) 316531, (Mouse) 22145