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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (YQVRIQPSIHDHN) corresponding to the internal amino acids of ITGAL|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-6µg/ml|
|Western Blot (WB)||0.5-2µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with canine based on sequence homology.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain to form the integrin lymphocyte function-associated antigen-1 , which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 , and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD11 antigen-like family member A, LFA-1 alpha, LFA-1A, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, integrin alpha-L, integrin gene promoter, leukocyte adhesion glycoprotein LFA-1 alpha chain, leukocyte function-associated molecule 1 alpha chain, lymphocyte function-associated antigen 1, antigen CD11A p180, lymphocyte function-associated antigen 1 alpha polypeptide
LFA-1, LFA1A, CD11A