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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (1044 DTEKHHPWAERPSSHD 1059) of NALP2 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NALP2 is a 1062 amino acid containing cytosolic protein, belonging to the NLRP family and is characterized by the presence of an N-terminal pyrin domain (PYD), eight leucine rich repeats and a NACHT domain. This protein is involved in the activation of caspase-1 by Toll-like receptors and may also be involved in protein complexes that activate proinflammatory caspases. The DAPIN domain of NALP2 helps in suppressing TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. NALP2 is known to interact with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. It is widely expressed in most of the tissues with high expression in lung, placenta and thymus, low expression in ovary, intestine and brain and variably in some cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLR19.9; leucine rich repeat and PYD containing 2; leucine rich repeat and pyrin domain containing 2; LRR and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NACHT, LRR and PYD domains-containing protein 2; NALP2; NBS1; NLR family, pyrin domain containing 2; nucleotide-binding oligomerization domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
CLR19.9; NALP2; NBS1; NLRP2; PAN1; PYPAF2