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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human DDB1 protein|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||2 µg/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.
37-6200 was used in western blot to investigate how ubiquitination of BK channels contributes to epilepsy.
|Liu J,Ye J,Zou X,Xu Z,Feng Y,Zou X,Chen Z,Li Y,Cang Y||Nature communications (5:null)||2014|
Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
||Hussain S,Feldman AL,Das C,Ziesmer SC,Ansell SM,Galardy PJ||Molecular and cellular biology (33:1188)||2013|
DDB p127 subunit, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-associated protein 1, UV-DDB 1, UV-damaged DNA-binding factor, UV-damaged DNA-binding protein 1, XAP-1, XPE-binding factor, xeroderma pigmentosum group E-complementing protein, DNA repair protein, damage-specific DNA-binding protein 1, damage-specific DNA-binding protein, DNA repair, damaged-DNA recognition protein 1, DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
DDBA, p127-Ddb1, XAP1, XPCE, AA408517, XPE-BF, UV-DDB1, 127kDa, XPE