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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Armenian hamster / IgG|
|Conjugate||Alexa Fluor® 488|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
ITGAX is the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
SHARPIN is essential for cytokine production, NF-¿B signaling, and induction of Th1 differentiation by dendritic cells.
MCD11c20 was used in flow cytometry to study the effects of SHARPIN-deficiency on dendritic cells.
|Wang Z,Sokolovska A,Seymour R,Sundberg JP,Hogenesch H||PloS one (7:null)||2012|
Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells.
MCD11c20 was used in flow cytometry and immunohistochemistry - frozen section to determine the fate of poly-lactic acid nanoparticles during their uptake at intestinal mucosal sites
|Primard C,Rochereau N,Luciani E,Genin C,Delair T,Paul S,Verrier B||Biomaterials (31:6060)||2010|
|Not Applicable||Not Cited||
CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth.
MCD11C20 was used in immunohistochemistry - frozen section to assess the effect of CD40 ligation on the survival of tumor-associated dendritic cells and tumor growth
|Esche C,Gambotto A,Satoh Y,Gerein V,Robbins PD,Watkins SC,Lotze MT,Shurin MR||European journal of immunology (29:2148)||1999|
AI449405; CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Cr4; Integrin alpha-X; integrin aX; ITGAX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; N418
AI449405; Cd11c; Cr4; Itgax; N418