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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Sf 21-derived recombinant human IL-12/IL-23 p40 free monomer Ile23-Ser328|
|Storage buffer||PBS with 5% trehalose|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-0.4 µg/ml (Detection), 2-8 µg/ml (Capture)|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In ELISAs, this antibody shows less than 5% cross-reactivity with recombinant human (rh) IL-12 (p35/p40 heterodimer) and rhIL-23 (p19/p40 heterodimer). No significant cross-reactivity or interference was observed with rhIL-1 alpha, rmIL-1 alpha, rhIL-1 beta, rmIL-1 beta, rhIL-1ra, rhIL-1 RI, rhIL-1 RII, rhIL-2, rhIL-2 R alpha, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-4 R, rhIL-5, rmIL-5, rhIL-5 R beta, rhIL-6, rhIL-6 R, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, rmIL-10, rhIL-11, rmIL-12, rmIL-12 p40, rhIL-13, or rmIL-13.
Reconstitute at 0.5 mg/mL in sterile PBS.
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLMF p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 p40; IL-12 subunit p40; Il-12b; Il-12p40; IL-23 subunit p40; IL12, subunit p40; IL12B; IL12P40; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; RP23-388G23.1
CLMF; CLMF2; IL-12B; IL12B; IMD28; IMD29; NKSF; NKSF2