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Apoptosis was induced as described in suggested protocol for apoptosis induction. The cells were fixed, permeabilized and stained with 10 µL/106 cells of the rabbit anti-PARP (214/215) FITC using the Staining Protocol (left-hand figure). In the right-hand
|Tested species reactivity||Bovine, Human|
|Published species reactivity||Artificial Control, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized peptide corresponding to N-terminus of cleavage site (214/215) of human PARP.|
|Storage buffer||PBS, pH 7.2, with BSA|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||Not Cited||Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss.||Salker MS,Nautiyal J,Steel JH,Webster Z,Sućurović S,Nicou M,Singh Y,Lucas ES,Murakami K,Chan YW,James S,Abdallah Y,Christian M,Croy BA,Mulac-Jericevic B,Quenby S,Brosens JJ||PloS one (7:null)||2013|
||Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest.||Raffoul JJ,Wang Y,Kucuk O,Forman JD,Sarkar FH,Hillman GG||BMC cancer (6:null)||2006|
|Artificial Control||Not Cited||Development of immunomodulatory six base-length non-CpG motif oligonucleotides for cancer vaccination.||Filion MC,Filion B,Roy J,Ménard S,Reader S,Phillips NC||Vaccine (22:2480)||2004|
|Human||Not Cited||Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.||Markova NG,Karaman-Jurukovska N,Dong KK,Damaghi N,Smiles KA,Yarosh DB||Free radical biology & medicine (46:1168)||2009|
|Artificial Control||Not Cited||Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest.||Raffoul JJ,Wang Y,Kucuk O,Forman JD,Sarkar FH,Hillman GG||BMC cancer (6:null)||2006|
||Development of immunomodulatory six base-length non-CpG motif oligonucleotides for cancer vaccination.||Filion MC,Filion B,Roy J,Ménard S,Reader S,Phillips NC||Vaccine (22:2480)||2004|
|Human||Not Cited||Induction of apoptosis in human lung cancer cells by curcumin.||Radhakrishna Pillai G,Srivastava AS,Hassanein TI,Chauhan DP,Carrier E||Cancer letters (208:163)||2004|
|Human||Not Cited||RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines.||Cioca DP,Aoki Y,Kiyosawa K||Cancer gene therapy (10:125)||2003|
|Human||Not Cited||Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines.||Yoshizawa K,Cioca DP,Kawa S,Tanaka E,Kiyosawa K||Cancer (95:2243)||2002|
|Human||Not Cited||Proliferation marker pKi-67 affects the cell cycle in a self-regulated manner.||Schmidt MH,Broll R,Bruch HP,Duchrow M||Journal of cellular biochemistry (87:334)||2002|
|Human||Not Cited||Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells.||Cioca DP,Kitano K||Cellular and molecular life sciences : CMLS (59:1377)||2002|
|Mouse||Not Cited||Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice.||Leemans JC,Juffermans NP,Florquin S,van Rooijen N,Vervoordeldonk MJ,Verbon A,van Deventer SJ,van der Poll T||Journal of immunology (Baltimore, Md. : 1950) (166:4604)||2001|
ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase); ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP-1; poly (ADP-ribose) polymerase 1; poly (ADP-ribose) polymerase family, member 1; Poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; Poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; PPOL
ADPRT; ADPRT 1; ADPRT1; ARTD1; BOS_15645; pADPRT-1; PARP; PARP-1; PARP1; PPOL